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Friday, April 16, 2010

Tripping for Evidence - Part 1

One of the nice things about Trip is its color-coding of what it finds based on the quality of the evidence.

Green is best. This includes evidence based synopses, guidelines and systematic reviews. Why is this best? Because people who know what they do already reviewed the available evidence, graded it and summarized it - all in all, less work for you!

Blue is for original research, i.e. research that you need to directly review and asses according to "best evidence" criteria.

Red and brown is for textbook based evidence (otherwise known as background evidence), news etc. - evidence that maybe informative but it's harder to asses in terms of validity and bias.

You would hope that you will find evidence clustering towards blue. In this instance though Trip doesn't find any "best evidence". You find only 3 articles, all original research. From those, there is only one clinical trial comparing asenapine (Saphris) with risperidone (Risperdal) in schizophrenia (Potkin 2007).

Good try but you need to move to step 2: SUMSearch.

N.B. In the future, if you want to try your own "trips" from this blog, you can go under the "search this" box and simply click on Trip Database.

For Part 2 of Tripping for Evidence please go HERE.

Potkin SG, Cohen M, Panagides J. Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial. J Clin Psychiatry. 2007 Oct;68(10):1492-500.

© Copyright Adrian Preda, M.D.

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